I fixed the room image in the title for you...it's much more useful to us if you choose the correct room when you make your post.
As for how to solve this room...there really aren't any tricks, you just need to get good at killing brained monsters. It's basically a marathon room. You can make it a little easier on yourself by dropping the trapdoors near the 2x2 blobs as soon as possible so that fewer babies spawn, but there will always be a small army that you need to deal with. Practice makes perfect...playing level 21 of KDD again might help your skills a bit.
Game on,
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"
He who is certain he knows the ending of things when he is only beginning them is either extremely wise or extremely foolish; no matter which is true, he is certainly an
unhappy man, for he has put a knife in the heart of wonder."
-- Tad Williams