The puzzle of this hold is to do things in the right order so that you do have enough health.
Hint 1:
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×What do you have to kill first? If the roach queen lays an egg, you can't kill the egg without an ATK of 24, which is unattainable in this room. The door won't open unless you kill everything.
Hint 2:
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×Hot tiles take off 5% of your HP. If there are hot tiles and potions, it's to your advantage to take the potions as late as possible so the bonus HP from the potion isn't also creamed by 5%.
Outright spoiler:
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×Leave the potion in the Entrance. Kill the roach queen. Go back to retrieve the potion. Kill the roaches.
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50th Skywatcher