Hi skip --
I remember that this room made me shudder when I first encountered it. Unfortunately, there is no real trick to it...like most many-queen rooms, it gets progressively easier as you kill more queens. If I recall correctly, I:
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×hit the queen right outside the wide passage first, then worked slowly north. If you can force the queens onto the little peninsulas it makes thing easier, as they can only spawn one roach per turn.
Good luck!
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"
Rings and knots of joy and grief, all interlaced and locking."
--William Buck