Having finally finished the game, my verdict would be that it's a really good game, but nowhere near groundbreaking. I played it on hard mode(which isn't all that difficult, as there were long stretches where I just used the wrench and the occasional freeze attack) and I found the story to be well done but terribly cliched (I could predict the entire story by the time you reach the first little sister).
I was also dissapointed that the game didn't force you to specialise more. I mean, you could use the machine gun ammo against anything, and with the exception of the camouflage plasmid there wasn't anything particularly fancy. I liked the research function to start with, there should have only been 2 or 3 tiers to reach, and many more varieties of enemies.
I applaud the use of an end boss, it has been far too long since I had a decent one, although the fact that I simply alternated between 3 weapons and 1 plasmid is kinda dissapointing.
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×which were the electrical ammo on the chemical thrower for the water stage, all the grenade launcher weapons for the electrical stage, and the shotgun for the fire stage. I used the enrage pasmid to turn the 'helpers' against Frank. The shorten alarm pasmids also came in handy.