Well clearly all the guards have to die. That's a bit of a simple way to put it. Now you may have figured this out but,
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×As far as I know the rooms aren't related to one another, so for all but the aumtlich one, which depends on your position (but not in a major way). Because of this you can try to solve each on its own.
Now this is the trickier part that you may not have figured out.
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×You have four fuses, so it seems like one should go in each room. This would be wrong, there is another way to detonate bombs that doesn't use the fuse.
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If you need to think outside of the box, then you didn't build a good enough box.