Generic rule is:
1. Watch the guards for a while - most of them have very simple looped move pattern. Loop period vary from 4 to 8 - that's not much to remember.
2. Plan your trajectory. Plan your sword position to hit the orb.
3. See at which turns your trajectory is clean: at any given moment you need two safe adjacent tiles - the one you're standing on and the one you're going to step on.
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×The trajectory to the orb in the third box is: W, SW, Pause, SW, Rotate, NE, E.
Anyway, why doing this?
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×First time you discover this room, you'd better quit it. Right now you cannot do anything useful in the room behind it. You'll just read some scrolls and go past these guards back :-)